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        深圳市艾斯基因科技有限公司成立于2016年4月,专注于新一代测序技术在生命科学研究和转化医学领域的产业化应用。创始团队成员来自英国剑桥大学、香港城市大学、厦门大学等国内外知名学府,拥有近10年的表观基因组学、调控基因组学、癌症基因组学、生物信息学等领域的科研及转化医学经验,在Nature Communications、Genome Biology、Cell Research、PNAS、Mol Biol Evol、Clinical Epigenetics、Epigenetics、Epigenomics等国际专业期刊发表40余篇学术论文。我们的核心价值是为广大科研工作者及基础医学研究提供专业的、有价值的表观组学为核心的多组学整体解决方案,与相关生物和医学领域的合作伙伴共同成长。



/团队成员发表文章/


[1] Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer. Clin Epigenetics. 2018;10:30.(IF=4.327)

[2] Early microbial colonization affects DNA methylation of genes related to intestinal immunity and metabolism in preterm pigs. DNA Res. 2018 Jan 19.(IF=5.415)

[3] Genome-wide DNA methylation analysis in jejunum of Sus scrofa with intrauterine growth restriction. Mol Genet Genomics. 2018;293(4):807-818.(IF=2.979)

[4] The association of changes in DNA methylation with temperature-dependent sex determination in cucumber. Journal of Experimental Botany. 2017;68(11):2899-2912.(IF=5.83)

[5] De novo DNA methylation during monkey pre-implantation embryogenesis. Cell Research. 2017;27:526-539. (IF=14.812)

[6] DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation. Genome Med. 2017;24;9(1):28.(IF=8.898)

[7] Cerberus-Nodal-Lefty-Pitx signaling cascade controls left-right asymmetry in amphioxus. Proc Natl Acad Sci USA. 2017;114(14):3684-3689.(IF= 9.15)

[8] Novel regional age-associated DNA methylation changes within human common disease-associated loci. Genome biology. 2016; 17: 193.(IF=11.313)

[9] Filtrating colorectal cancer associated genes by integrated analyses of global DNA methylation and hydroxymethylation in cancer and normal tissue. Scientific reports. 2016; 6: 31826.(IF=5.228)

[10] Contribution of Heritability and Epigenetic Factors to Skeletal Muscle Mass Variation in United Kingdom Twins. The Journal of clinical endocrinology and metabolism. 2016; 101: 2450-9.(IF=5.531)

[11] DNA methylation landscape of fat deposits and fatty acid compositionin obese and lean pigs. Scientific Reports. 2016;6:35063.(IF=5.228)

[12] Stochastic anomaly of methylome but persistent SRY hypermethylation in disorder of sex development in canine somatic cell nuclear transfer. Scientific reports. 2016; 6: 31088.(IF=5.228)

[13] The promoter methylomes of monochorionic twin placentas reveal intrauterine growth restriction-specific variations in the methylation patterns. Scientific reports. 2016; 6:20181.(IF=5.228)

[14] Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridization capture-based bisulfite sequencing approach. Clin Epigenetics. 2015;7:86. (IF=4.327)

[15] Improved tagmentation-based whole-genome bisulfite sequencing for input DNA from less than 100 mammalian cells. Epigenomics. 2015; 7: 47-56.(IF=4.044)

[16] A transcription/translation-based gene signature predicts resistance to chemotherapy in breast cancer. Journal of pharmaceutical and biomedical analysis. 2015; 102: 500-8.(IF=3.169)

[17] Clustering of Cancer Cell Lines Using A Promoter- Targeted Liquid Hybridization Capture-Based Bisulfite Sequencing Approach. Technology in cancer research & treatment. 2015; 14: 383-94. (IF=2.185)

[18] Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5, and EOMES in human hepatocellular carcinoma. Genome biology. 2014; 15: 533.(IF=11.313)

[19] Marked methylation changes in intestinal genes during the perinatal period of preterm neonates. BMC genomics. 2014; 15: 716.(IF=3.867)

[20] A 20-gene signature in predicting the chemoresistance of breast cancer to taxane-based chemotherapy. Molecular bioSystems. 2014; 10: 3111-9.(IF=2.829)

[21] Genome-wide DNA methylation changes in skeletal muscle between young and middle-aged pigs. BMC genomics. 2014; 15: 653.(IF=3.867)

[22] An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins. Nature communications. 2014; 5: 5719.(IF=11.329)

[23] DNA methylation and mRNA and microRNA expression of SLE CD4+ T cells correlate with disease phenotype. Journal of autoimmunity. 2014; 54: 127-36.(IF=7.76)

[24] Hypermethylation in the ZBTB20 gene is associated with major depressive disorder. Genome biology. 2014;15(4):R56.(IF=11.313)

[25] Decelerated genome evolution in modern vertebrates revealed by analysis of multiple lancelet genomes. Nature communications. 2014; 5:5896.(IF=11.329)

[26] High-throughput sequencing of methylated cytosine enriched by modification-dependent restriction endonuclease MspJI. BMC Genetics. 2013;14:56.(IF=2.152)

[27] Double restriction-enzyme digestion improves the coverage and accuracy of genome-wide CpG methylation profiling by reduced representation bisulfite sequencing. BMC genomics. 2013; 14: 11.(IF=3.867)

[28] Sorafenib inhibits epithelial-mesenchymal transition through an epigenetic-based mechanism in human lung epithelial cells. PloS one. 2013; 8: e64954.(IF=3.057)

[29] Hydroxymethylation- and methylation-sensitive tag sequencing: how will this technology change clinical applications of DNA methylation profiling? Epigenomics. 2013; 5: 355-7.(IF=4.044)

[30] Integrated detection of both 5-mC and 5-hmC by high-throughput tag sequencing technology highlights methylation reprogramming of bivalent genes during cellular differentiation. Epigenetics. 2013; 8: 421-30.(IF=4.327)

[31] Differential DNA methylation in discrete developmental stages of the parasitic nematode Trichinella spiralis. Genome biology. 2012; 13: R100.(IF=11.313)

[32] An atlas of DNA methylomes in porcine adipose and muscle tissues. Nature communications. 2012; 3: 850.(IF=11.329)

[33] Co-methylated genes in different adipose depots of pig are associated with metabolic, inflammatory and immune processes. International journal of biological sciences. 2012; 8: 831-7.(IF=3.982)

[34] The evolutionarily dynamic IFN-inducible GTPase proteins play conserved immune functions in vertebrates and cephalochordates. Mol Biol Evol. 2009; 26(7):1619-30.(IF=10.217)

[35] Comparison of Pax1/9 locus reveals 500-Myr-old syntenic block and evolutionary conserved noncoding regions. Mol Biol Evol. 2007;24(3):784-91.(IF=10.217)


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